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Microbiology and Biotechnology Letters


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Enzymes and Bioactive Compounds

Microbiol. Biotechnol. Lett. 2014; 42(4): 331-338

Received: March 10, 2014; Accepted: September 25, 2014

점액세균 Myxococcus stipitatus KYC4013에 의한 생리활성물질 생산

Production of Bioactive Substances by a Myxobacterium Myxococcus stipitatus KYC4013

Dongju An 1, Soohyun Park 1, Jong Suk Lee 2 and Kyungyun Cho 1*

1Department of Biotechnology, Hoseo University, Asan 336-795, Republic of Korea, 2Gyeonggi Bio Center, Gyeonggi Institute of Science & Technology Promotion, Suwon 443-270, Republic of Korea

Myxococcus stipitatus KYC4013 extract exhibited the most potent antifungal activity among the extracts of 207 Myxococcus strains isolated in Korea. High-resolution LC-MS analysis revealed that M. stipitatus KYC4013 produces five antifungal substances and three other secondary metabolites that were predicted to be melithiazol and phenalamide derivatives, respectively. The putative melithiazol derivatives were best produced in CYS medium and the putative phenalamide derivatives were best produced in VY3 medium.

Keywords: Myxococcus stipitatus, myxobacteria, melithiazol, phenalamide

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