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Microbiology and Biotechnology Letters

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Microbiol. Biotechnol. Lett. 2010; 38(4): 405-413

병원내에서 분리된 메티실린내성 황색포도상구균에 대한 무화과잎 추출물의 항미생물효과

Synergistic Antibacterial Activity of Fig (Ficus carica) Leaves Extract Against Clinical Isolates of Methicillin-resistant Staphylococcus aureus

Young-Soo Lee and Jeong-Dan Cha

Department of Dental Hygiene, Sunmoon University, 1Department of Dental Hygiene, College of Natural Sciences, Dongeui University

Abstract

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Fig (Ficus carica L.) belongs to the mulberry tree (Moraceae) which is one of the oldest fruits in the world. It has been used as a digestion promoter and a cure for ulcerative inflammation and eruption in Korea. The present study investigated the antimicrobial activity of methanol (MeOH) extract of fig leaves against methicillin-resistant Staphylococcus aureus (MRSA) isolated in clinic. The MeOH extract (MICs, 2.5 to 20 mg/mL; MBCs, 5 to 20 mg/mL) was demonstrated as antibacterial activity in isolates MRSA 1-20. The administration of the MeOH extract in combination with oxacillin or ampicillin induced a reduction of ${geq}$4-8-fold in all tested bacteria, which was considered to be synergistic based on a FICI of ${leq}$0.375-0.5. Furthermore, time-kill study was found that a combination of MeOH extract with oxacillin or ampicillin produced a more rapid decrease in the concentration of bacteria CFU/mL than MeOH extract alone. The results suggest that fig leaves could be employed as a natural antibacterial agent in MRSA infection care products.

Keywords: Ficus carica (fig), methicillin-resistant Staphylococcus aureus, antibacterial activity, minimum inhibitory concentration, minimum bactericidal concentration, synergistic effect

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