Contact us
닫기
Article Search
닫기

Microbiology and Biotechnology Letters

Research Article(보문)

View PDF

Molecular and Cellular Microbiology (MCM)  |  Microbial Genetics, Physiology and Metabolism

Microbiol. Biotechnol. Lett. 2024; 52(4): 441-447

https://doi.org/10.48022/mbl.2408.08008

Received: August 9, 2024; Revised: September 20, 2024; Accepted: September 27, 2024

Selected D7 Antibody Inhibit Cancer Cell Growth

Chi Hun Song and Kyung Ho Han*

Department of Biological Sciences and Biotechnology, Hannam University, Daejeon 34054, Republic of Korea

Correspondence to :
Kyung Ho Han,    kyungho1@hnu.kr

Abstract

Go to

We developed to screen for antibodies that promote cell growth in serum-free conditions using a human antibody library. The antibody library was engineered to be anchored near the cell surface and delivered to cells using a lentivirus to introduce the antibody genes. When treated cells cultured under serum-free conditions, viable cells were obtained and antibodies were selected by PCR. Although selected D7 antibody did not induce cell growth and proliferation under serum-free conditions as initially expected, we unexpectedly discovered that D7 antibody significantly inhibits MCF cancer cells in 10% FBS condition. Overall, our findings suggest that D7 antibody, discovered through this novel method, is a promising candidate for future cancer therapies.

Keywords: Antibody, serum, antibody library, cancer

Graphical Abstract


Article Tools

Starts of Metrics

Share this article on :

Related articles in MBL

Most Searched Keywords ?

What is Most Searched Keywords?

  • It is most registrated keyword in articles at this journal during for 2 years.