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Microbiology and Biotechnology Letters


Food Microbiology  |  Bioactive Compounds or Metabolites: Function and Application

Microbiol. Biotechnol. Lett.

Received: April 7, 2022; Revised: June 10, 2022

Anti-inflammatory effect of Carex scabrifolia Steud. extract in RAW264.7 cells

Joong Hyun Shim 1, 1, 1*

Semyung Univ.

Correspondence to :
Joong Hyun Shim, 65, Semyung-ro, Jecheon, Chungbuk, Korea [26490]
Tel : +821041448102, Fax : 82436491730, E-mail :


This research was designed to evaluate the possible anti-inflammatory effects of Carex scabrifolia Steud. extract on the skin using RAW 264.7 cells. The assessments of these effects were based on cell viability assay, mRNA expression levels of interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β), IL-6, tumor necrosis factor alpha (TNFα), and levels of nitric oxide (NO)/prostaglandin E2 (PGE2) production. Quantitative real-time polymerase chain reaction showed that treatment with C. scabrifolia Steud. extract decreased the mRNA levels of iNOS, COX2, IL-1α, IL-1β, IL-6, and TNFα. Furthermore, from the production levels of PGE2/NO, it can be inferred that C. scabrifolia Steud. extract exhibited anti-inflammatory properties. These results suggest that C. scabrifolia Steud. extract contains anti-inflammatory compound(s). Consequently, the extract may be a potent cosmeceutical material for anti-inflammatory effects against atopic dermatitis. Taken together, further studies on the anti-inflammatory mechanisms of C. scabrifolia Steud. extract would not only facilitate the development of cosmeceutical but also engender pharmacological treatments.

Keywords: Carex scabrifolia Steud., inflammation, iNOS, COX2, interleukins, TNFα

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