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Microbiology and Biotechnology Letters

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Food, Environment, and Other Topics in Biotechnology

Microbiol. Biotechnol. Lett. 2016; 44(1): 19-25

https://doi.org/10.4014/mbl.1510.10002

Received: October 12, 2015; Accepted: January 9, 2016

잔가시 모자반 추출물의 주름 개선 및 미백 효과

Anti-Melanogenesis and Anti-Wrinkle Effects of Sargassum micracanthum Extracts

Won-Min Pak 1, Koth-Bong-Woo-Ri Kim 2, Min-Ji Kim 1, Ji-Hye Park 1, Nan-Young Bae 1, Sun-Hee Park 1 and Dong-Hyun Ahn 1*

1Department of Food Science & Technology / Institute of Food Science, Pukyong National University, Busan 48513, Republic of Korea, 2Institute of Fishries Sciences, Pukyong National University, Busan 46041, Republic of Korea

Abstract

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Sargassum micracanthum (SM) is a member of the family Sargassaceae and commonly occurs along the coast of Korea. Extracts from SM were evaluated for their antioxidant and collagenase and tyrosinase inhibitory activities based on their total phenolic concentration (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging effect, and metal-chelating effect. The TPC of SM ethanol and water extracts used in the study was 11.20 and 11.70 mg/g of dry sample, respectively. Both SM ethanol and water extracts had high DPPH radical-scavenging effect. The metal-chelating effect of SM ethanol extract (40.47% at 0.5 mg/ml) was higher than that of water extract (23.28% at 0.5 mg/ml). With regard to the antiwrinkling effect, SM ethanol extract showed collagenase inhibitory activity with an IC50 value of 488.20 μg/ ml. Lastly, regarding the anti-melanogenesis effect, SM ethanol extract showed higher tyrosinase inhibitory activity (45.08% at 5 mg/ml) than that shown by the water extract (21.29% at 5 mg/ml). These results suggest that SM has the potential to be a resource with natural anti-melanogenesis, anti-wrinkle, and antioxidant effects..

Keywords: Sargassum micracanthum, antioxidant activity, tyrosinase inhibitory activity, collagenase inhibitory activity

References

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  1. Blois MS. 1958. Antioxidant determinations by the use of a stable free radical. Nature 181: 1990−2100.
    CrossRef
  2. Choi BW, Lee BH, Kang KJ, Lee ES, Lee NH. 1998. Screening of the tyrosinase inhibitors from marine algae and medicinal plants. Korean J. Pharmacogn. 29: 237−242.
  3. Choi HJ, Park JH, Han HS, Son JH, Son GM, Bae JH, et al. 2004. Effect of polyphenol compound from Korean pear (Pyruspyrifolia Nakai) on lipid metabolism. Korean J. Food Sci. Technol. 33: 299−304.
  4. Decker EA, Hultin HO. 1992. Lipid oxidation in muscle foods via redox iron, pp. 1-11. In St. Angelo AJ (ed.), Lipid oxidation in food. ACS Symposium Series 500, Washington, D.C.
  5. El-Domyati M, Attia S, Saleh F, Brown D, Birk DE, Gasparro F, et al. 2002. Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin. Exp. Dermatol. 11: 398−405.
    Pubmed CrossRef
  6. Gilchrest BA, Eller MS. 1999. DNA photodamage stimulates melanogenesis and other photoprotective responses. J. Investig. Dermatol. Symp. Proc. 4: 35−40.
    Pubmed CrossRef
  7. Goldberg I. 1994. Functional foods. pp. 3-550. Chapman & Hall Inc. New York.
    Pubmed CrossRef
  8. Grant NH, Alburn HE. 1959. Studies on the collagenases of Clostridium histolyticum. Arch. Biochem. Biophys. 82: 245−255.
    CrossRef
  9. Ham YM, Kim KN, Lee WJ, Lee NH, Hyun CG. 2010. Chemical constituents from Sargassum micracanthum and antioxidant activity. Int. J. Pharmacol. 6: 147−151.
    CrossRef
  10. Hwang RC, Hwang IG, Kim HY, Kang TS, Kim YB, Joo SS, et al. 2011. Antioxidant component and activity of dropwort (Oenanthe javanica) ethanol extracts. J. Korean Soc. Food Sci. Nutr. 40: 316−320.
    CrossRef
  11. Imokawa G, Mishima Y. 1980. Isolation and characterization of tyrosinase inhibitors and their differential action on melanogenic subcelluar compartments in amelanotic and melanomas. Br. J. Dermatol. 103: 625−633.
    Pubmed CrossRef
  12. Jenkins NC, Grossman D. 2013. Role of melanin in melanocyte dysregulation of reactive oxygen species. Biomed Res. Int. 2013:1−3.
    Pubmed KoreaMed CrossRef
  13. Jeon SM, Kim SY, Kim IH, Go JS, Kim HR, Jeong JY, et al. 2013. Antioxidant activities of processed Deoduck (Codonopsis lanceolata) extracts. J. Korean Soc. Food Sci. Nutr. 42: 924−932.
    CrossRef
  14. Jeong DH, Kang BK, Kim KBWR, Kim MJ, Ahn DH. 2014. Antiinflammatory activity of Sargassum micracanthum water extract. J. Appl. Biol. Chem. 57: 227−234.
    CrossRef
  15. Jeong DH, Kim KBWR, Kim MJ, Kang BK, Bark SW, Pak WM, et al. 2014. Anti-atopic activity of Sargassum micracanthum ethanol extracts. Microbiol. Biotechnol. Lett. 42: 82−88.
    CrossRef
  16. Jeroma SP, Gabrielle L, Raul F. 1998. Identification of collagen fibrils in scleroderma skin. J. Invest. Dermatol. 90: 48−54.
  17. Jiménez-Cervantes C, Solano F, Kobayashi T, Urabe K, Hearing VJ, Lozano JA, et al. 1994. A new enzymatic function in the melanogenic pathway. The 5,6-dihydroxyindole-2-carboxylic acid oxidase activity of tyrosinase-related protein-1 (TRP1). J. Biol. Chem. 269: 17993−18000.
    Pubmed
  18. Jun HJ, Lee SY, Kim JH, An BJ, Lee JY. 2013. Anti-wrinkling effects of Juniperus rigida Sieb. Korean J. Microbiol. Biotechnol. 41: 449−455.
    CrossRef
  19. Kim DM, Kim KH, Sung NY, Jung PM, Kim JS, Kim JK, et al. 2011. Effects of gamma irradiation on the extraction yield and whitening activity of polysaccharides from Undaria pinnatifida Sporophyll. J. Korean Soc. Food Sci. Nutr. 40: 712−716.
    CrossRef
  20. Kim J, Uyama H. 2005. Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future. Cell. Mol. Life Sci. 62: 1707−1723.
    Pubmed CrossRef
  21. Kim JA, Karadeniz F, Ahn BN, Kwon MS, Mun OJ, Kim M, et al. 2014. Sargassum sp. attenuates oxidative stress and suppresses lipid accumulation in vitro. J. Life Sci. 24: 274−283.
    CrossRef
  22. Kim JH, Kang HM, Lee SH, Lee JY, Park LY. 2015. Antioxidant and α-glucosidase inhibition activity of seaweed extracts. Korean J. Food Preserv. 22: 290−296.
    CrossRef
  23. Kim SH, Jun DH, Jang MJ, Lee JT, Lee CE, Han J, et al. 2010. Study of cosmeceutical activities of Hovenia dulcis var. koreana Nakai extracts. J. Korean For. Soc. 99: 836−842.
  24. Labuza TP, Jr LRD. 1971. Kinetics of lipid oxidation in foods. CRC Crit. Rev. Food Technol. 2: 335−405.
    CrossRef
  25. Laskin JD, Piccinini LA. 1986. Tyrosinase isozyme heterogeneity in differentiating B-16/C3 melanoma. J. Biol. Chem. 261: 16626−16635.
    Pubmed
  26. Lee JY, Choi YH, Lee SM, Lee SY, Jun HJ. 2012. Physiological activity of Aconitum pseudolaeve var erectum Nakai and its effect on perfume on an electroencephalogram (EEG). J. Life Sci. 22: 1214−1223.
    CrossRef
  27. Lee SJ, Song EJ, Lee SY, Kim KBWR, Yoon SY, Lee CJ, et al. 2010. Effects of gamma irradiation on antioxidant, antimicrobial activities and physical characteristics of Sargassum thunbergii extract. Korean J. Food Sci. Technol. 42: 431−437.
  28. Lee YJ, Yoon BR, Choi HS, Lee BY, Lee OH. 2012. Effect of Sargassum micracanthum extract on lipid accumulation and reactive oxygen species (ROS) production during differentiation of 3T3L1 preadipocytes. Korean J. Food Preserv. 19: 455−461.
    CrossRef
  29. Park JM, Kim KJ. 2010. The anti-wrinkle effects and whitening effects of Galla rhois. J. Korean Orient. Med. Ophthalmol. Otolaryngol. Dermato. 23: 135−148.
  30. Porto CD, Calligaris S, Cellotti E, Nicoli MC. 2000. Antiradical properties of commercial cognacs assessed by the DPPH test. J. Agric. Food Chem. 48: 4241−4245.
    Pubmed CrossRef
  31. Pyo YH, Yoon MY, Son JH, Choe TB. 2008. The effect of Celosia cristata L. ethanol extract on anti-oxidant & anti-aging. Korean J. Biotechnol. Bioeng. 23: 431−438.
  32. Rittié L, Fisher GJ. 2002. UV-light-induced signal cascades and skin aging. Ageing Res. Rev. 1: 705−720.
    CrossRef
  33. Satue-Garcia MT, Heinonen IM, Frankel EN. 1997. Anthocyanins as antioxidants on human low-density lipoprotein and lecithin liposome system. J. Agric. Food Chem. 45: 3362−3367.
    CrossRef
  34. Seo IA. 2010. Studies on cosmeceutical of Phaseolus radiatus. MS. dissertation, Daegu Haany University, Gyeongbuk, Korea.
  35. Shimada K, Fujikawa K, Yahara K, Nakamura T. 1992. Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. J. Agric. Food Chem. 40: 945−948.
    CrossRef
  36. Swain T, Hillis WE. 1959. The phenolic constituents of Prunus domestica. I.-The quantitative analysis of phenolic constituents. J. Sci. Food Agric. 10: 63−68.
    CrossRef
  37. Tsai TC, Hantash BM. 2008. Cosmeceutical agents: A comprehensive review of the literature. Clin. Med. Insights Dermatol. 27: 1−20.
  38. Wang Y, Johnson AR, Ye QZ, Dyer RD. 1999. Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain. J. Biol. Chem. 274: 33043−33049.
    Pubmed CrossRef
  39. Wunsch E, Heindrich HG. 1963. Zur qutitativen bestimmung der collagenase. Hoppe-Seyler's Z. Physiol. Chem. 333: 149−151.
    CrossRef
  40. Yoo JG. 2010. Effect of natural plant’s water extracts on melanin biosynthesis in mouse melanoma cell (B16F10) and human skin cell (CCD-986sk). MS Thesis. Kangwon National University, Gangwondo, Korea.

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