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Microbiology and Biotechnology Letters

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Microbiol. Biotechnol. Lett. 2009; 37(1): 42-48

수종의 한약재 추출물의 항산화 활성 및 항진균 활성

Biological and Antifungal Activity of Herbal Plant Extracts against Candida Species

Jae-Young Kim , Yong-Sub Yi and Yoong-Ho Lim

Department of Herbal Cosmetic Science, Hoseo University, 1Department of Herbal Cosmetic Science, Hoseo University, 2BMIC, Department of Bioscience and Biotechnology, Konkuk University

Abstract

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Anticandidial activity of seven herbal extracts, Taraxacum Platycarpum, Houttuyniae Herba, Lonicerae Flos, Anemarrhena Rhizome, Forsythia Fruit, Paeoniae Ratix, and Coptidis Rhizoma, were determined against five different Candida sp. by agar diffusion assay. The concentration of total phenolic compounds of seven herbal extracts ranged from 0.6 to $2.5{mu}g/mg$. The total antioxidant activities showed that Taraxacum Platycarpum and Houttuyniae Herba were 60% in 80% ethanol extract and Lonicera Flower and Paeoniae Ratix were 70, 75%, respectively, in 100% ethanol extract. Coptidis Rhizoma extract showed antifungal activity against non-Candida albicans, C. tropicalis and C. glabrata. The MIC values of a compound separated in TLC from Coptidis Rhizoma extract were 24, and $48{mu}g/mL$ against C. tropicalis and C. glabrata. The above compound showed the same retention time with berberin in HPLC analysis.

Keywords: Anticandidial activity, antioxidant, Candida species, Coptidis Rhizoma

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