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Microbiology and Biotechnology Letters

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Microbiol. Biotechnol. Lett. 2007; 35(3): 238-244

시판 전통주의 항균, 항산화 및 항혈전 활성 평가

Evaluation for the Antimicrobial, Antioxidant and Anti-thrombosis Activity of Korean Traditional Liquors

Hee-Young Ryu , Eun-Joo Kum , Kyung-Hwa Bae , Young-Kwan Kim , In-Sook Kwun and Ho-Yong Sohn

Department of Food and Nutrition, Andong National University, 1Institute of Korean Medicine and Biomedical Science, 2Department of Food and Nutrition, Andong National University, 3Gyeongbuk Institute for Bioindustry, 4Department of Food and Nutrition, Andong National University, 5Department of Food and Nutrition, Andong National University

Abstract

To identify the useful biological activities and the superiority in quality of Korean traditional liquors, we prepared the alcohol-free concentrates from different types of commercial traditional liquors, Takju ($T1{sim}T3$), Yakju/Cheongju ($Y-1{sim}Y-5$), Fruit wine (F-1) and Soju (S-1, S-2), respectively. We investigate their compositions as well as antimicrobial, antioxidant, and anti-thrombosis activity. Among the 11 traditional liquors, Y-3, Y-4, Y-5 and F-1 showed higher total-polyphenol, total-flavonoids and reducing sugars than the others. The strong antibacterial and anti-thrombosis activities were identified in Y-3, Y-4, Y-5 and F-1, and a minor antioxidant activity was found in F-l. The antibacterial activity of the Y-3, Y-4, Y-5 and F-1 alcohol-free concentrates showed a broad-spectrum, and growth inhibition was found in gram-positive, gram-negative, and ampicillin-resistant bacteria. The sequential solvent fractionation of Y-3, Y-4, Y-5 and F-1, and following analysis showed that ethyl acetate fractions of Y-3, Y-4, Y-5 and F-1 possess strong antibacterial and anti-thrombosis activity. Especially, the ethyl acetate fractions of Y-3, Y-4 and F-1 showed superior anti-thrombosis activity compared than that of aspirin. Our results suggest that the useful substances are produced from substrates and edible plant added during the fermentation, and the Korean traditional liquors could be developed as strong antibacterial and anti-thrombosis agents.

Keywords: Antimicrobial, antioxidant, anti-thrombosis, korean traditional liquors

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