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Microbiology and Biotechnology Letters

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Microbiol. Biotechnol. Lett. 1992; 20(6): 699-703

간염 치료제인 민간제제의 성분 분석 및 생리 활성 검색

Component Analysis and Determination of Bioactivity of Oriental Therapeutic Drug for Hepatitis B

Abstract

An oriental drug, named NP-S, traditionally used as a therapeutic agent for hepatitis B was characterized by separating into volatile and non-volatile fractions. The volatile fraction contained ammonia as determined by ammonia kit and eight peaks when it was analyzed by gas chromatography that are not identified yet. The elemental analysis showed that the non-volatile fraction contained 15.5% carbon, 4.8% hydrogen, 11% nitrogen, and 10% sulfur along with a few trace elements such as Cl, Si, Mg and Zn. NP-S contained 6.7% peptide, 0.3% free amino acids such as Lys, Pro, Arg, lie, Tyr, Phe, His, Thr and Ser and 0.1% inorganic phosphate. The drug showed antimicrobial activity against Salmonella typhimurium, StaPhylococcus aureus and Candida albieans and also had antioxidant activity when thiobarbituric acid reacting substances(TBARS) method was applied.

Keywords: Hepatitis, antimicrobial activity, antioxidant

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