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Microbiology and Biotechnology Letters


Molecular and Cellular Microbiology  |  Host-Microbe Interaction and Pathogenesis

Microbiol. Biotechnol. Lett.

Received: May 31, 2024

The innate immune viral sensors and their functional crosstalk

Ji-Seung Yoo 1*

School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University

Correspondence to :
Ji-Seung Yoo, 80, Daehak-ro, Buk-gu, Daegu, Republic of Korea. Kyungpook National University, Integrated Natural Science Building, Room 628 [41566]
Fax : 053-950-5378, E-mail :


The precise and elaborate regulation of signaling cascades by diverse cytoplasmic and endosomal antiviral sensors is crucial for maintaining immune homeostasis and defending against viral pathogens. Receptors and enzymes that recognize foreign nucleic acids play a pivotal role in inducing antiviral interferon programs, serving as the first line of defense against various DNA and RNA viruses. Recent research has increasingly highlighted the crosstalk between nucleic acid sensors in detecting multiple virus invasions, resulting in amplified antiviral signals and compensating for any missing roles. This review provides an update on recent findings regarding the interplay of RNA sensors for DNA virus recognition.

Keywords: Antiviral innate immunity, RNA virus sensors, DNA virus sensors, Interferon, inflammation, host-microbe interaction

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