Article Search
닫기

Microbiology and Biotechnology Letters

Genome Report(Note)

Genome Report  |  Genome Report

Microbiol. Biotechnol. Lett.

Received: March 9, 2024

Draft Genome Sequence of Mycobacterium abscessus Treated with a Fluoroquinolone in a Time-Dependent Manner

Du-Gyeong Han 1, Ji-A Jeong 1, Sung-Kyoung Lee 1, Seong-Han Kim 1 and Se-Mi Jeon 1*

Korea National Institute of Health

Correspondence to :
Se-Mi Jeon, 187, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, Korea [28159]
Tel : +82-43-719-8462, Fax : +82-43-719-8489, E-mail : sem21c@korea.kr

Abstract

This study aimed to confirm the induction of resistance to other drug classes by treating Mycobacterium abscessus with moxifloxacin, a fluoroquinolone used for treating nontuberculous mycobacteria infection, and to obtain genetic data for improving treatment. The reads were assembled and analyzed using reference strain sequence data, and the whole-genome and transcriptome sequences of four strains (MD2, MD4, MD6, and MD8) were reported. Antibiotic resistance was not induced by moxifloxacin treatment; however, transcriptomic analysis revealed that the expression of genes responding to stress was upregulated.

Keywords: Mycobacterium abscessus, genome, transcriptome, moxifloxacin, resistance, fluoroquinolone

Starts of Metrics

Share this article on :

Related articles in MBL

Most Searched Keywords ?

What is Most Searched Keywords?

  • It is most registrated keyword in articles at this journal during for 2 years.