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Microbiology and Biotechnology Letters

보문(Article)

Molecular and Cellular Microbiology  |  Microbial Genetics, Physiology and Metabolism

Microbiol. Biotechnol. Lett.

Received: May 7, 2022; Revised: July 21, 2022

Analysis of hepatitis C virus genotypes and RNA quantitative values in Cheonan, Korea, from 2007 to 2016

Bishguurmaa Renchindorj 1, 보경 정 2 and 주원 박 3*

1Dankook University Graduate School , 2Dankook University College of Medicine, 3Dankook University College of Medicine

Correspondence to :
주원 박, 충남 천안시 동남구 망향로 201 [31116]
Tel : 0415506662, Fax : 0415507055, E-mail : joowon@dankook.ac.kr

Abstract

The hepatitis C virus (HCV) genome contains a positive-sense single-stranded RNA molecule, and can be classified into eight genotypes and 87 subtypes. Globally, over 350,000 people die from liver cirrhosis and hepatocellular carcinoma caused by HCV each year. Here, the genotype distribution of HCV was estimated among the population in Cheonan, Korea using Sanger sequencing. Further, the correlation between HCV RNA level and genotype was assessed using real-time PCR, as was the correlation of HCV RNA level with isolation year (2007–2016) using 463 consecutive serum samples obtained from patients at Dankook University Hospital, Cheonan, Korea. In 2007, genotype 1b (54.2%) was predominant, followed by genotypes 2a (41.7%), 1a (2.1%), and 3a (2.1%); whereas in 2016, the predominant genotype was 2a (49.0%), followed by genotypes 1b (46.9%), 3b (2%), and 4a (2%). Neither age nor sex were correlated with HCV genotype. Further, the mean HCV RNA level decreased significantly from 2012 to 2016 (p < 0.05). However, no significant correlations between genotype and HCV RNA level were found. Overall, the findings revealed that genotypes 2a and 1b were the most common in Cheonan, and the prevalence of HCV genotype 1b tended to decrease over the past decade.

Keywords: Hepatitis C virus, genotype, Korea, RNA quantitative value

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