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Microbiology and Biotechnology Letters


Fermentation Microbiology  |  Strain Isolation and Improvement

Microbiol. Biotechnol. Lett.

Received: April 13, 2022; Revised: July 20, 2022; Accepted: July 20, 2022

Characterization of Weizmannia ginsengihumi LGHNH from wild-ginseng and anti-aging effects of its cultured product

Minjung Kwon 1, Hyejin Lee 1, So Young Lee 1 and Mu Hyun Jin 1*

LG H&H Co., Ltd. R&D Center

Correspondence to :
Mu Hyun Jin, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul [07795]
Tel : +82-2-6980-1554, Fax : +82-2-6980-1602, E-mail :


In this study, we isolated Weizmannia ginsengihumi LGHNH (KCTC 14462BP) from 30-year-old wild Panax ginseng C.A. Meyer and elucidated the characteristics of the isolated bacteria and its industrial potential as an anti-aging material. W. ginsengihumi LGHNH was investigated to produce indole-3-acetic acid (IAA), a plant growth promoting hormone (1.38 μg/mL to 2.22 μg/mL). Also, it was confirmed that there is a bioconversion activity via the comparison of the ginsenoside content before and after fermentation. As for the converted minor ginsenoside, Rg2(R), Rg4, Rg6, Rg3(S), Rg3(R), Rk1, Rg5, Rh1(R), Rk3 and Rh4 are known to have high bioavailability and various skin effects. We measured mitochondrial membrane potential and ATP biosynthesis to elucidate W. ginsengihumi LGHNH cultured product (WCP) as an anti-aging material. As a result, the mitochondrial membrane potential in HaCaT cells with UVB decreased to 39.3% compared to the unirradiated group, but was recovered to 57.3% and 58.1% by 0.001% (v/v) and 0.01% (v/v) WCP, respectively. In addition, we measured mitochondrial ATP biosynthesis. It decreased to 94.3% compared to the unirradiated group with UVB, but was recovered to 105.3% and 105.7% by 0.001% (v/v) and 0.01% (v/v) WCP.

Keywords: Wild Panax ginseng, Weizmannia ginsengihumi, Endophytes, Anti-aging

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