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Microbiology and Biotechnology Letters


Molecular and Cellular Microbiology  |  Host-Microbe Interaction and Pathogenesis

Microbiol. Biotechnol. Lett.

Received: May 27, 2022; Revised: July 15, 2022

IgY: A key isotype and promising antibody for the immunoprophylaxis therapy of infectious bursal disease virus infections

Sanaullah Sajid 1, 1, 1*

University of Agriculture Faisalabad

Correspondence to :
Sanaullah Sajid, University of Agriculture Faisalabad [38000]
Fax : +923202545454, E-mail :


The infectious bursal disease is a highly contagious and acute poultry disease caused by Birnavirus. However, vaccination is the only prevention of the disease, but several factors impeded vaccine development. Thus, a need for time to develop a novel technique for managing and treating respiratory diseases in poultry birds. Passive immunization is a hope and a possible alternative used in birds to meet this need. The current research attempted to produce egg yolk-based polyclonal antibodies against the IDB virus. The benefits of IgY include ease of extraction, lack of reaction with mammalian Fc receptors, and low production cost. Commercial layers were immunized with inactivated IBD virus subcutaneously according to the treatment regimen. The eggs were gathered every day, and yolk antibodies were extracted with the ammonium sulfate precipitation technique. The use of an indirect hemagglutination test demonstrated the IBD-specific IgY. Until the end of the experiment, the specific IgY immunoglobulins did not lose activity when stored at 4℃. The infectious bursal disease-challenged birds were treated with specific IgY antibodies that induced 92% recovery in birds in comparison to the control group. The study implies that the IBDV-specific IgY is an easily prepared and rich source of antibodies and offers an alternative therapeutic agent to cure IBD-infected birds.

Keywords: Immunoglobulin-Y, Immunoprophylaxis, Passive Immunization, IBDV

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