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Microbiology and Biotechnology Letters

보문(Article)

Food Microbiology  |  Probiotics in Nutrition and Health

Microbiol. Biotechnol. Lett.

Received: June 25, 2022; Revised: July 8, 2022

Effect of synbiotics added feed on growth and immune response, disease resistance in olive flounder, Paralichthys olivaceus

ChaeYun Moon 1, HongJu Son 2 and MoonSoo Heo 1*

1Department of Aquatic Life Medicine, Jeju National University, Jeju 63243, Korea, 2Department of Life science and Environmental Biochemistry, Pusan National University, Pusan, 50463, Korea

Correspondence to :
MoonSoo Heo, Department of Aquatic Life Medicine, Jeju National University, Jeju [63243]
Tel : +82-64-754-3473, Fax : +82-64-756-3493, E-mail : msheo@jejunu.ac.kr
, Department of Life science and Environmental Biochemistry, Pusan National University, Pusan [50463]
Tel : +82-55-350-5544, Fax : +82-55-350-5549

Abstract

In this study, probiotics and inulin 3% were mixed, and the effect of the synbiotic mixture on the growth, non-specific immune response, and mortality due to disease resistance of Paralichthys olivaceus were investigated. The results revealed that the 8-weeks feeding of the synbiotics, had no significant effect on the growth of P. olivaceus, The analysis of the hematological parameters revealed that there was a significant difference in the content of AST, total protein, and cholesterol among the groups, whereas there was no significant difference in the ALT and glucose contents. Further, there was no significant difference in the lysozyme activity of the synbiotic and control group after 8 weeks feeding. In addition, when the symbiotic mixture was used rather than probiotics alone, the NBT activity of the synbiotic group increased compared to that of the control group. Further, when only probiotics was used, the cytokine expression in the spleen of the samples was significantly lower than that in the control group, whereas the expression was significantly higher in the spleen of the synbiotics group. However, there was no significant difference in the cytokine expression in the liver, intestine, and kidney of the three groups. Lastly, after injection for 2 weeks, the mortality rates of the control group towards Edwardsiella tarda, Streptococcus parauberis, and Streptococcus iniae were 95, 85 and 85%, respectively; those of the probiotics group were 85, 80, and 80%, respectively; and those of the synbiotics group were 80, 80, and 85%, respectively.

Keywords: Synbiotics, Probiotics, Prebiotics, Paralichthys olivaceus, non-specific immune, Bacillus cabrialesii

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