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Microbiology and Biotechnology Letters

보문(Article)

Molecular and Cellular Microbiology  |  Host-Microbe Interaction and Pathogenesis

Microbiol. Biotechnol. Lett.

Received: December 29, 2021; Revised: April 12, 2022

Protective effect of Paulownia tomentosa fruits in an experimental animal model of acute lung injury

Seong-Man Kim 1, Hyung Won Ryu 1, Ok-Kyoung Kwon 1, Jae-Hong Min 1, Jin-Mi Park 1, Doo-Young Kim 1, Sei-Ryang Oh 1, Seung Jin Lee , Kyung-Seop Ahn 1 and Jae-Won Lee 1*

1Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 2College of Pharmacy, Chungnam National University, 3College of Pharmacy, Chungbuk National University

Correspondence to :
Jae-Won Lee, Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Cheongju 28116, Republic of Korea [28116]
Tel : +82 43 240 6135, Fax : 82-43-240-6129, E-mail : suc369@kangwon.ac.kr

Abstract

The fruits of Paulownia tomentosa (Thunb.) (PT) Steud. have been reported to exert a variety of biological activities. A previous study confirmed that compounds isolated from PT fruits (PTF) exerted anti-inflammatory effects on tumor necrosis factor-α (TNF-α)-stimulated airway epithelial cells. However, there is no report on the protective effects of PTF on acute lung injury (ALI). The present study examined the ameliorative effects of PTF in an experimental animal model of lipopolysaccharide (LPS)-induced ALI. In ALI mice, the increased levels of inflammatory cell influx were confirmed in the lungs of mice, and an increase of microphage numbers and TNF-α, IL-6 and monocyte chemoattractant protein-1 production was detected in mouse bronchoalveolar lavage fluid (BALF). However, this increase was significantly reversed with PTF pretreatment. In addition, PT inhibited the increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in the lungs of ALI mice. Furthermore, the upregulation of MAPK and NF-κB activation was decreased in the lungs of ALI mice by PTF. In the in vitro experiment, PTF pretreatment exerted an anti-inflammatory effect by inhibiting the secretion of nitric oxide, TNF-α and IL-6 in LPS-stimulated RAW264.7 macrophages. Collectively, these results indicated that PT has ameliorative effects on airway inflammation in an experimental animal model of ALI.

Keywords: acute lung injury, Paulownia tomentosa fruits, macrophage, cytokines, NF-κB

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