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Molecular and Cellular Microbiology | Host-Microbe Interaction and Pathogenesis
Microbiol. Biotechnol. Lett.
Boram Jeon 1, Hangeun Kim 2* and Dae Kyun Chung 1, 2, 3
1Kyung Hee University, 2Skin Biotechnology Center Co., Ltd., 3Kyung Hee University
Correspondence to :
Hangeun Kim, Research and Development Center, Skin Biotechnology Center Co., Ltd., Kyung Hee University, Yongin 
Tel : 82-31-201-2487, Fax : 82-31-888-6173, E-mail : email@example.com
Lipoteichoic acid (LTA) is known to regulate the immune system, including inflammatory responses, through TLR2-mediated signaling pathways. LTA isolated from Staphylococcus aureus (aLTA) is known to induce apoptosis of cells, but the detailed mechanism has not been identified. aLTA induced apoptosis through autocrine function in a THP-1 human monocyte-like cell line. We observed that expression of the anti-apoptosis protein Bcl2 is suppressed in LTA-treated THP-1. In addition, the cytokines TNF-? and IFN-γ, which are known to induce apoptosis in some cell lines, are involved in cell death via modulation of Bcl2. Suppression of Bcl2 by aLTA was recovered when negative regulator SOCS-1 is knocked out. Taken together, lipoteichoic acid from S. aureus induced apoptosis in THP-1 through autocrine function of cytokines and SOCS-1-mediated Bcl2 inhibition.
Keywords: Lipoteichoic acid, S. aureus, apoptosis, Bcl2, SOCS-1, Cytokines
Ho KimMicrobiol. Biotechnol. Lett. 2022; 50(1): 157-163 https://doi.org/10.48022/mbl.2108.08004
Hyeong-Seon LeeMicrobiol. Biotechnol. Lett. 2021; 49(3): 283-288 https://doi.org/10.48022/mbl.2102.02009
Van-Tinh Nguyen , Seok-Chun Ko , Gun-Woo Oh , Seong-Yeong Heo and Won-Kyo JungMicrobiol. Biotechnol. Lett. 2019; 47(1): 43-53 https://doi.org/10.4014/mbl.1806.06001