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Microbial Biotechnology | Cell Culture and Biomedical Engineering
Microbiol. Biotechnol. Lett.
Si-Hyang Park 1, Kyong-Dong Lee 2, Ginnae Ahn 3, Hye-Jin Park 4, Kap Seong Choi 5, Jiyeon Chun 5 and Sun-Yup SHIM 5*
1Sunmarine Biotech Co. Ltd, 2Dongsin University, 3Chonnam National University, 4Changshin University, 5Sunchon National University
Correspondence to :
Sun-Yup SHIM, Department of Food Science and Biotechnology, College of Life Science and Natural Resources, Sunchon National University, 255 Jungang-ro, Suncheon-Si 57922, Republic of Korea 
Tel : +82-61-750-3250, Fax : +82-61-750-3250, E-mail : email@example.com
Microalgae, Tetrathelmis Tetrathele is used as various production development in aquaculture, food and nutraceutical industries. In the present study, we investigated whether the T. Tetrathele ethanolic extract (TTE) with anti-inflammatory activities confer protection against alopecia and improve scalp health, or influence the proliferation of human keratinocytes, HaCaT cells and human hair follicle dermal papilla cells (HFDPC), and HFDPC inhibits 5 alpha- reductase activity. TTE inhibited the production of the inflammatory mediator, nitric oxide (NO) and prostaglandin E2 (PGE2) without cytotoxicity in LPS-stimulated RAW 264.7 cells. In addition, TTE proliferated HaCaT cells and HFDPC. Our results shown that TTE with anti-inflammatory activities, proliferated HaCaT cells and HFDPC, and inhibited activity of 5 alpha reductase. Therefore, we suggested that T. Tetrathele may be potent therapeutic biomass on alopecia prevention and scalp improvement.
Keywords: Tetraselmis Tetrathele, nitric oxide, prostanglandin E2, keratinocytes, human hair follicle dermal papilla cells, 5-alpha reductase
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