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Microbiology and Biotechnology Letters

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Molecular and Cellular Microbiology (MCM)  |  Microbial Genetics, Physiology and Metabolism

Microbiol. Biotechnol. Lett. 2021; 49(2): 264-268

https://doi.org/10.48022/mbl.2101.01009

Received: January 20, 2021; Revised: March 2, 2021; Accepted: March 3, 2021

Metabolite Profiling of Serum from Patients with Tuberculosis

Hee-Bin Park1†, Min-Gyu Yoo2†, Sangho Choi1, Seong-Han Kim1, and Hyuk Chu1*

1Division of Bacterial Disease Research, Center for Infectious Diseases Research, National Institute of Infectious Disease (NIID), 2Division of Endocrine and Kidney Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28160, Republic of Korea

Correspondence to :
Hyuk Chu,       chuhyuk@korea.kr

Tuberculosis (TB) is a major infectious disease that threatens the life and health of people globally. Here, we performed a metabolomic analysis of serum samples from patients with intractable TB to identify biomarkers that might shorten the TB treatment period. Serum samples collected at the commencement of patients’ treatment and healthy controls were analyzed using the capillary electrophoresis and time-offlight mass spectrometry metabolome analysis method. The analysis identified the metabolites cystine, kynurenine, glyceric acid, and cystathionine, which might be useful markers for monitoring the TB treatment course. Furthermore, our research may provide experimental data to develop potential biomarkers in the TB treatment course.

Keywords: Biomarker, CE-TOFMS, mycobacterium tuberculosis, metabolites

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