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Microbiology and Biotechnology Letters


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Molecular and Cellular Microbiology (MCM)  |  Microbiome

Microbiol. Biotechnol. Lett. 2022; 50(1): 135-146

Received: February 3, 2022; Revised: February 18, 2022; Accepted: February 19, 2022

생쥐 비만모델에서 Weissella confusa WIKIM51 식이에 따른 지방합성 및 에너지 대사 조절로 인한 체지방 감소 효과

Oral Administration of Weissella confusa WIKIM51 Reduces Body Fat Mass by Modulating Lipid Biosynthesis and Energy Expenditure in Diet-Induced Obese Mice

Seul Ki Lim1, Jieun Lee2, Sung Soo Park3, Sun Yong Kim4, Sang Min Park4, Ji Ye Mok4, Hyunah Chang4, and Hak-Jong Choi3*

1Fermentation Regulation Technology Research Group, World Institute of Kimchi, Gwangju 61755, Republic of Korea , 2Industrial Solution Research Group, World Institute of Kimchi, Gwangju 61755, Republic of Korea, 3Kimchi Functionality Research Group, World Institute of Kimchi, Gwangju 61755, Republic of Korea, 4Pharmsville Co., Ltd., Seoul 07793, Republic of Korea

Correspondence to :
Hak-Jong Choi,

Obesity is closely associated with profound dyslipidemia, insulin resistance, and fatty liver disease. Recent reports have suggested that alterations in gut microbiota can be linked to diet-induced obesity. In this study, the anti-obesity effects of Weissella confusa WIKIM51 isolated from kimchi were investigated, as evidenced by: i) reduced lipid accumulation and downregulated adipogenesis-related genes in 3T3-L1 adipocytes; ii) suppressed gains in body weight and epididymal fat mass; iii) reduced serum lipid levels, for example, triglyceride and total cholesterol; iv) increased serum adiponectin levels and reduced serum leptin levels; v) downregulated lipogenesis and upregulated β-oxidation-related genes in the epididymal fat; and vi) altered microbial communities. The collective evidence indicate the potential value of W. confusa WIKIM51 as a functional food supplement for the prevention and amelioration of obesity.

Keywords: Weissella confusa, lactic acid bacteria, anti-obesity activity, Kimchi

Graphical Abstract

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