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Microbiology and Biotechnology Letters

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Food Microbiology (FM)  |  Bioactive Compounds or Metabolites: Function and Application

Microbiol. Biotechnol. Lett. 2022; 50(1): 15-21

https://doi.org/10.48022/mbl.2111.11001

Received: November 1, 2021; Revised: December 22, 2021; Accepted: January 17, 2022

Anti-Inflammatory Effects of the Chemical Compounds Obtained from Celastrus hindsii in RAW264.7 Cells

Thi Ngoc Anh Pham1, Hae Lim Kim1, Suwon Oh1,2, and Seung Hwan Yang1*

1Department of Biotechnology, Chonnam National University, Yeosu 59626, Republic of Korea 2Marine Biotechnology Research Center, Jeonnam Bioindustry Foundation, Wando 59108, Republic of Korea

Correspondence to :
Seung Hwan Yang,       ymichigan@jnu.ac.kr

Celastrus hindsii (family Celastraceae) is located abundantly in the United States, China, and Vietnam, where it is utilized as a traditional herbal and traditional drug for the care of cancer. However, the antioxidant and anti-inflammatory effects of Celastrus hindsii extract are unknown. In our research, the antioxidant activity of Celastrus hindsii leaf extract was investigated, and then anti-inflammatory efficacy of C. hindsii extract in lipopolysaccharide (LPS)-induced RAW264.7 cells. First, our results revealed that C. hindsii extract showed powerful antioxidant capability. Moreover, the application of C. hindsii extract significantly reduced nitric oxide (NO) production without cytotoxic effects. Furthermore, C. hindsii extract reduced the generation of pro-inflammatory cytokines, like as interleukin (IL)-6, IL-1β, and TNF-α. Our results are the first to confirm the anti-inflammatory capability of C. hindsii extract in RAW264.7 cells.

Keywords: Anti-inflammatory, Celastrus hindsii, nitric oxide, proinflammatory cytokines, RAW264.7 macrophages

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