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Microbiology and Biotechnology Letters


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Fermentation and Bioprocess Engineering

Microbiol. Biotechnol. Lett. 2014; 42(3): 297-301

Received: July 14, 2014; Accepted: August 20, 2014

표면적이 증가된 반코마이신 결정화 공정에서 이온성 액체의 영향

Effect of Ionic Liquid on Increased Surface Area Crystallization Process for Vancomycin

Sung-Jae Kim 1 and Jin-Hyun Kim 1*

Department of Chemical Engineering, Kongju National University, Cheonan 331-717, Republic of Korea

We examined the effect of ionic liquid on the crystallization efficiency of vancomycin in an increased surface area crystallization with silica gel. The crystallization efficiency was improved by the addition of ionic liquid, [BMIm][BF4]. The addition of ionic liquid (20%, v/v) on the increased surface area crystallization with silica gel dramatically reduced the crystallization time by 6 folds (4 h), compared with the results of the case where the surface area-increasing material and ionic liquid had not been added. In addition, the crystal size of vancomycin was decreased and the crystal quality of vancomycin was improved by increasing the addition of ionic liquid.

Keywords: Vancomycin, Increased surface area crystallization, Silica gel, Ionic liquid

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