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Microbiology and Biotechnology Letters


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Bioactive Compounds / Food Microbiology  |  Food Biotechnology

Microbiol. Biotechnol. Lett. 2017; 45(4): 284-290

Received: July 13, 2017; Accepted: October 17, 2017

와송추출물의 비만유발 ICR 마우스에서의 항비만 효과

Anti-obesity Effects of the Water Extract from Orostachys japonicus in High-fat Diet-Fed Mice

Kyungsun Lee 1 and Hyeong-Seon Lee 2*

1Department of Integrated Biomedical and Life Science, Graduated School, Korea University, Seoul 02841, Republic of Korea, 2Department of Biomedical Laboratory Science, Jungwon University, Goesan 28024 , Republic of Korea

We investigated the anti-obesity effects of the water extract from Orostachys japonicus in high-fat-fed mice. For the analysis, 24 mice were divided into four groups: normal (N) group, high-fat diet (HFD) group, highfat diet supplemented with 2.5% O. japonicus (HFD-OJL) group, and high-fat diet supplemented with 5% O. japonicus (HFD-OJH) group. The body weight gain and food efficiency ratio increased with a high-fat diet, but significantly decreased in the HFD-OJ groups compared with those in the HFD group. Levels of serum triglyceride, total cholesterol, and LDL-cholesterol were significantly lower, but the HDL-cholesterol level was significantly higher in the HFD-OJH group. The adipocytes within the epididymal adipose tissue were found to have expanded in the HFD group. However, the adipocytes in the HFD-OJ groups were comparable to those of the N group. These results suggest that O. japonicus has potential as an anti-obesity agent by decreasing body weight and lowering the serum lipid levels in obese mice.

Keywords: Orostachys japonicus, high fat diet, adipocyte size, anti-obesity, mice

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